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M K Quinn et al.
Physical chemistry chemical physics : PCCP, 17(46), 31177-31187 (2015-11-07)
A complete understanding of the role of molecular anisotropy in directing the self assembly of colloids and proteins remains a challenge for soft matter science and biophysics. For proteins in particular, the complexity of the surface at a molecular level
Jianbo Zhu et al.
Physical chemistry chemical physics : PCCP, 17(43), 28666-28673 (2015-10-08)
In this work, polypyrrole/graphene doped by p-toluenesulfonic is prepared as an active material for supercapacitors, and its capacitance performance is investigated in various aqueous electrolytes including HCl, LiCl, NaCl, and KCl with a concentration of 3 M, respectively. A rising
Paolo Piatti et al.
Scientific reports, 5, 8007-8007 (2015-01-27)
The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and pluripotency in embryonic stem cells (ESCs). Here we have studied the effects of a partial deletion
Shanlu Liang et al.
Nanotoxicology, 9(1), 92-105 (2014-03-14)
In the past few years, much work has been performed to explore the biomedical applications and toxicity of nano-graphene and its derivatives. However, the reproductive toxicity of those carbon nanomaterials has been rarely studied. In this study, we report on
Alex Yong Sheng Eng et al.
Nanoscale, 7(47), 20256-20266 (2015-11-19)
Chemical modification and functionalization of inherent functional groups within graphite oxide (GO) are essential aspects of graphene-based nano-materials used in wide-ranging applications. Despite extensive research, there remains some discrepancy in its structure, with current knowledge limited primarily to spectroscopic data
A Kaufmann et al.
Analytica chimica acta, 862, 41-52 (2015-02-16)
An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran and chloramphenicol residues in a number of animal based food products. This method is based
Daniel Rycroft et al.
PloS one, 10(2), e0117847-e0117847 (2015-02-18)
Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure to interferon. We therefore hypothesise that targeting IFN directly to the intended site
Karolien Hollanders et al.
Investigative ophthalmology & visual science, 56(2), 1335-1348 (2015-01-30)
Rho kinase (ROCK) is associated with VEGF-driven angiogenesis, as well as with inflammation and fibrosis. Therefore, the effect of AMA0428, a novel ROCK inhibitor, was studied in these processes, which highly contribute to the pathogenesis of neovascular AMD. The effect
Enamel color modifications by controlled hydrochloric acid pumice abrasion: a review with case summaries.
T C Adams
Journal (Indiana Dental Association), 66(5), 23-26 (1987-09-01)
Elizabeth A Ennis et al.
ACS chemical neuroscience, 6(3), 417-427 (2015-01-07)
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a high-throughput screen for
Miyeoun Song et al.
Cell transplantation, 24(2), 183-190 (2014-01-02)
The long-term effect of magnetically targeted neural stem cells in a rat focal cerebral ischemia model was investigated. In middle cerebral artery occlusion (MCAO) stroke model rats, ferumoxide-labeled human neural stem cells (hNSCs) were injected into the tail vein. MCAO
Evelien A W Smits et al.
Journal of liposome research, 25(1), 46-57 (2014-07-02)
Besides the development of sample preparation methods for the determination of separate liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine plasma and blood, this article also presents the first description of an accurate sample preparation method for the determination
Johanna Kaartinen et al.
Veterinary journal (London, England : 1997), 202(2), 353-360 (2014-09-10)
The haemodynamic interactions of a step infusion with medetomidine (MED) and the peripherally acting alpha-2 antagonist MK-467 (MK) were compared with MED infused alone in isoflurane-anaesthetised dogs. Eight purposely-bred Beagles were used in a randomised crossover study. Anaesthesia was induced
Chisato Wakabayashi et al.
Psychopharmacology, 232(24), 4393-4400 (2015-09-12)
High-fat diet (HFD) has been recently reported to induce sensorimotor gating deficits, but the underlying mechanisms are not well understood. The purpose of this study is to determine whether HFD induces long-lasting deficits in sensorimotor gating and to examine the
Juan F Callejas et al.
ACS nano, 8(11), 11101-11107 (2014-09-25)
Nanostructured transition-metal phosphides have recently emerged as Earth-abundant alternatives to platinum for catalyzing the hydrogen-evolution reaction (HER), which is central to several clean energy technologies because it produces molecular hydrogen through the electrochemical reduction of water. Iron-based catalysts are very
Dragana P Srebro et al.
The Tohoku journal of experimental medicine, 234(4), 287-293 (2014-12-09)
The N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor, may play a significant role in the development and maintenance of an inflammatory pain. Activation of NMDA receptors may cause nitric oxide (NO) release through activation of NO synthase (NOS). MK-801, a
Motoko Sasaki et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(3), 1024-1035 (2014-04-10)
Combined hepatocellular-cholangiocarcinoma (cHC-CC), a malignant liver tumour with poor prognosis, is composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and diverse components with intermediate features between HCC and CC, which correspond to hepatic progenitor cells. According to the WHO classification 2010
Valentina Lulli et al.
Oncotarget, 6(35), 37241-37256 (2015-10-06)
Glioblastoma multiforme (GBM) is the most common and fatal malignant adult primary brain tumor. Currently, the overall prognosis for GBM patients remains poor despite advances in neurosurgery and adjuvant treatments. MicroRNAs (miRNAs) contribute to the pathogenesis of various types of
Dawn A Sim et al.
Disease models & mechanisms, 8(11), 1479-1487 (2015-09-24)
We have developed a method to label and image myeloid cells infiltrating the mouse retina and choroid in vivo, using a single depot injection of indocyanine green dye (ICG). This was demonstrated using the following ocular models of inflammation and
M Jenda et al.
Progress in neuro-psychopharmacology & biological psychiatry, 57, 166-175 (2014-12-03)
Previous studies have indicated that metabotropic glutamate receptors 7 (mGluR7s) are involved in drug addiction. However, the role of these receptors in drug-induced behavioral sensitization is unknown. The aim of the present study was to determine whether systemic injection of
Maha Hegazy et al.
Journal of chromatographic science, 52(9), 1071-1081 (2013-11-20)
A simple and sensitive stability indicating HPLC method was developed and validated for quantitative determination of Nitazoxanide (NTZ), a new antiprotozoal drug, in presence of degradation products generated under forced alkaline hydrolysis. Chromatographic separation was achieved on Inertsil C8-3 column
José M Garcia et al.
The Lancet. Oncology, 16(1), 108-116 (2014-12-20)
Cancer anorexia-cachexia syndrome is associated with increased morbidity and mortality. Anamorelin is an oral ghrelin-receptor agonist with appetite-enhancing and anabolic activity. We assessed the effects of anamorelin on body composition, strength, quality of life, biochemical markers, and safety in patients
Lukas Horvath et al.
Audiology & neuro-otology, 20(1), 51-61 (2014-11-28)
Activin, a member of the TGF-F superfamily, was found to play an important role in the development, repair and apoptosis of different tissues and organs. Accordingly, activin signaling is involved in the development of the cochlea. Activin binds to its
Daniel E Morrison et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(50), 16602-16612 (2014-10-18)
A structure-activity relationship study of a library of novel bifunctional Gd(III) complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential application in binary cancer therapies such as neutron capture therapy and photon activation therapy.
Marco Ragazzi et al.
Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA, 31(3), 235-240 (2013-02-01)
This article presents the case study of a waste incinerator located in a region rich in natural and environmental resources, and close to the city of Bozen, where there are about 100,000 inhabitants. Local authorities paid special attention to the
Miriam Payá-Milans et al.
Phytochemistry, 111, 27-36 (2015-01-27)
The acyl-[acyl carrier protein]:sn-1-glycerol-3-phosphate acyltransferase (GPAT; E.C. 2.3.1.15) catalyzes the first step of glycerolipid assembly within the stroma of the chloroplast. In the present study, the sunflower (Helianthus annuus, L.) stromal GPAT was cloned, sequenced and characterized. We identified a
María J Trujillo-Rodríguez et al.
Analytical and bioanalytical chemistry, 407(29), 8753-8764 (2015-09-26)
The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic IL-based surfactant 1,3-didodecylimidazolium bromide (C12C12Im-Br) studied for first time in m-μdSPE, but double-salt (DS)
Makiko Shimizu et al.
Drug metabolism and pharmacokinetics, 30(1), 70-74 (2015-03-12)
Human flavin-containing monooxygenase 3 (FMO3) in the liver catalyzes a variety of oxygenations of nitrogen- and sulfur-containing medicines and xenobiotic substances. Because of growing interest in drug interactions mediated by polymorphic FMO3, benzydamine N-oxygenation by human FMO3 was investigated as
Nicole Abdul et al.
Scientific reports, 5, 16469-16469 (2015-11-11)
Total knee arthroplasty (TKA) is one of the most successful orthopaedic procedures that alleviates pain and restores function in patients with degenerative knee joint diseases. Arthrofibrosis, abnormal scarring in which dense fibrous tissue prevents normal range of motion, develops in
Masashi Morita et al.
Metabolic brain disease, 30(6), 1359-1367 (2015-06-26)
The dysfunction of ABCD1, a peroxisomal ABC protein, leads to the perturbation of very long chain fatty acid (VLCFA) metabolism and is the cause of X-linked adrenoleukodystrophy. Abcd1-deficient mice exhibit an accumulation of saturated VLCFAs, such as C26:0, in all
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