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SMB00914

Sigma-Aldrich

Isovanillic Acid 3-Sulfate Disodium Salt

≥96% (HPLC)

Synonym(s):

Isovanillic acid 3-sulfate disodium salt

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About This Item

Empirical Formula (Hill Notation):
C8H6Na2O7S
CAS Number:
78061-96-8
Molecular Weight:
292.17
UNSPSC Code:
12352205
NACRES:
NA.25

Assay

≥96% (HPLC)

form

powder

color

, White to off-white

solubility

water: 40 mg/mL

storage temp.

2-8°C

SMILES string

COC(C=C1)=C(OS(=O)(O[Na])=O)C=C1C(O[Na])=O

General description

Isovanillic acid 3-O-sulfate (IVAS) is a gut microbial phenolic metabolite primarily derived from consumed cyanidin 3-O-glucoside, a major compound in berry fruits. IVAS is the most effective among the gut microbial phenolic metabolites tested to enhance glucose uptake & metabolism in human skeletal muscle myoblast LHCN-M2. IIVAS is shown to increase glucose transport via GLUT4- and PI3K-dependent mechanisms. IVAS also upregulates GLUT1, GLUT4, PI3K p85a protein level, and Akt phosphorylation, establishing a novel link between gut microbiota, host diet and skeletal muscle energy source utilization.Also another study shows that IVAS restores glycosaminoglycans (GAGs) level and reduce inflammatory markers in diabetic human aortic endothelial cells (HAECs).

Other Notes

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SMB00914-BULK:
SMB00914-VAR:
SMB00914-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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