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Safety Information

RAB0971

Sigma-Aldrich

Phosphotyrosine JAK2 / Tyrosine-protein Kinase JAK2 ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

technique(s)

ELISA: suitable

assay range

inter-assay cv: <10%
intra-assay cv: <12%

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... JAK2(3717)

Related Categories

General description

The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-JAK2. The JAK2 (Janus kinase 2) gene is mapped to human chromosome 9p24.1.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Janus kinase 2 (JAK2) mediates epithelial-mesenchymal transition in hepatocellular carcinoma. The JAK2/STAT3 signaling pathway is associated with tumor development in a number of cancer such as gastric cancer. Mutation in the JAK2 gene is known to activate JAK2 receptor action even in the absence of ligand, inducing cell proliferation and opposing apoptosis.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABHRP6Phosphotyrosine ELISA HRP-StreptavidinSDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Please refer to KIT Component information

PRTR

Please refer to KIT Component information

FSL

Please refer to KIT Component information

ISHL Indicated Name

Please refer to KIT Component information

ISHL Notified Names

Please refer to KIT Component information

Cartagena Act

Please refer to KIT Component information

JAN Code

キットコンポーネントの情報を参照してください

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
Zhou J, et al.
Oncology Reports, 38(2), 1059-1066 (2017)
The genetic basis of haematological cancers (2016)
CD 274 (PDL 1) and JAK 2 genomic amplifications in pulmonary squamous?cell and adenocarcinoma patients.
Clave S, et al.
Histopathology, 72(2), 259-269 (2018)
Norcantharidin inhibits IL-6-induced epithelial?mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Gao Y, et al.
Oncology Reports, 38(2), 1224-1232 (2017)

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