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H1664

Sigma-Aldrich

Hemokinin 1 human

≥98% (HPLC), solid

Synonym(s):

hHK-1

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About This Item

Empirical Formula (Hill Notation):
C54H82N14O14S
CAS Number:
491851-53-7
Molecular Weight:
1183.38
MDL number:
MFCD06656083
UNSPSC Code:
12352202
PubChem Substance ID:
329815175
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white

UniProt accession no.

Q86UU9

shipped in

wet ice

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](N)[C@@H](C)O)C(N)=O

InChI

1S/C54H84N14O14S/c1-30(2)24-38(51(79)64-35(46(58)74)21-23-83-5)63-44(73)27-59-48(76)39(25-33-14-8-6-9-15-33)66-52(80)40(26-34-16-10-7-11-17-34)67-50(78)37(19-20-42(56)71)65-53(81)41(29-69)68-47(75)31(3)61-49(77)36(18-12-13-22-55)62-43(72)28-60-54(82)45(57)32(4)70/h6-11,14-17,30-32,35-41,45,69-70H,12-13,18-29,55,57H2,1-5H3,(H2,56,71)(H2,58,74)(H,59,76)(H,60,82)(H,61,77)(H,62,72)(H,63,73)(H,64,79)(H,65,81)(H,66,80)(H,67,78)(H,68,75)/t31-,32+,35-,36-,37-,38-,39-,40-,41-,45-/m0/s1

InChI key

NYBLUYYRUFKGTB-XJCFQSCISA-N

Gene Information

human ... TAC4(255061)

Amino Acid Sequence

Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2

General description

Hemokinin 1 (HK1) is a a member of the tachykinin peptide family with broad expression, particularly in brain areas.

Biochem/physiol Actions

Hemokinin 1 (HK1) is an endogenous agonist for all tachykinin receptors. However, it is highly selective for the NK1 (neurokinin 1) receptor. HK1 and substance-P compete with each other for binding to NK1. HK1 is involved in the B-cell as well as T-cell development.
NK1 tachykinin receptor agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H1664-VAR:
H1664-1MG:
H1664-1MG-PW:
H1664-BULK:

Certificates of Analysis (COA)

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Riccardo Patacchini et al.
Trends in pharmacological sciences, 25(1), 1-3 (2004-01-16)
The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a widespread peripheral distribution and a tachykinin NK(1) receptor selectivity. This
R A Duffy et al.
Neuropharmacology, 45(2), 242-250 (2003-07-05)
Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies suggest HK-1 may have a role in immunological functions, but there
Nigel M Page et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(10), 6245-6250 (2003-04-30)
We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and
Yu Zhang et al.
Blood, 102(6), 2165-2172 (2003-06-07)
Hemokinin 1 (HK-1) is a new member of the tachykinin peptide family that is expressed in hematopoietic cells. Recent reports studying mouse, rat, and human orthologs of HK-1 demonstrate a broader distribution than originally reported. Our previous studies demonstrated that
Stanislas Grassin-Delyle et al.
Respiratory research, 11, 139-139 (2010-10-12)
Human hemokinin-1 (hHK-1) and endokinins are peptides of the tachykinin family encoded by the TAC4 gene. TAC4 and hHK-1 expression as well as effects of hHK-1 in the lung and airways remain however unknown and were explored in this study.

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