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451M-1

Sigma-Aldrich

h-Caldesmon (hHCD) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

hHCD, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (451M-14)
vial of 0.1 mL concentrate Research Use Only (451M-14-RUO)
vial of 0.5 mL concentrate (451M-15)
vial of 1.0 mL concentrate (451M-16)
vial of 1.0 mL concentrate Research Use Only (451M-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (451M-17)
vial of 7.0 mL pre-dilute ready-to-use (451M-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)

isotype

IgG1

control

bladder, colon, leiomyoma, smooth muscle tumors, stomach

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Related Categories

General description

Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

451M-16:
451M-18-RUO:
451M-13:
451M-14:
451M-15:
451M-17-RUO:
451M-12:
451M-11:
451M-18:
451M-15-RUO:
451M-17:
451M-14-RUO:
451M-16-RUO:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K M Ceballos et al.
American journal of clinical pathology, 114(5), 746-753 (2000-11-09)
Misinterpretation of positive staining of antibodies to desmin, smooth muscle actin, and muscle actin as representing smooth muscle differentiation in the context of a spindle cell tumor is not uncommon. Anti-h-caldesmon is a promising novel immunohistochemical reagent for more specific
M R Nucci et al.
The American journal of surgical pathology, 25(4), 455-463 (2001-03-21)
Distinction of endometrial stromal neoplasms from cellular smooth muscle tumors of the uterus is sometimes difficult. Immunohistochemistry is often not helpful because muscle actins and desmin are expressed in both neoplasms. This study's goal was to determine whether h-caldesmon, a

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