Salicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

2-Hydroxybenzoic acid
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:


certified reference material
pharmaceutical secondary standard

Quality Level

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)




current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


211 °C (lit.)


158-161 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to BP 775
traceable to PhEur S020000
traceable to USP 1609002

SMILES string




InChI key


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General description

Salicylic acid is an important material in pharmaceutical industry, obtained via the decomposition of acetylsalicylic acid. Salicylic acid is widely used in food industry for producing dyes and artificial scents. It also shows therapeutic potential in protecting the skin from sun damage and hence finds applications in cosmetics and medicine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Salicylic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrofluorometric technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC3036 in the slot below. This is an example certificate only and may not be the lot that you receive.




NONH for all modes of transport

WGK Germany


Flash Point F

314.6 °F - closed cup

Flash Point C

157 °C - closed cup

Certificate of Analysis

Certificate of Origin

Simultaneous determination of naproxen, salicylic acid and acetylsalicylic acid by spectrofluorimetry using partial least-squares (PLS) multivariate calibration
Navalon A, et al.
Talanta, 48(2), 469-475 (1999)
Nickel?aluminum layered double hydroxide as a nanosorbent for selective solid-phase extraction and spectrofluorometric determination of salicylic acid in pharmaceutical and biological samples
Abdolmohammad-Zadeh H, et al.
Talanta, 84(2), 368-373 (2011)
Shifeng Cao et al.
Food chemistry, 134(4), 1715-1718 (2013-02-28)
The effect of elicitors associated with host defence on betacyanin accumulation in Amaranthus mangostanus seedlings was investigated. Under the conditions of the experiments, betacyanin accumulation was generally enhanced by light. Methyl jasmonate (MeJA) treatment increased betacyanin synthesis in a concentration-dependent...
Zheng Qing Fu et al.
Annual review of plant biology, 64, 839-863 (2013-02-05)
Systemic acquired resistance (SAR) is an induced immune mechanism in plants. Unlike vertebrate adaptive immunity, SAR is broad spectrum, with no specificity to the initial infection. An avirulent pathogen causing local programmed cell death can induce SAR through generation of...
S G Owen et al.
British journal of clinical pharmacology, 38(4), 349-355 (1994-10-01)
1. Five rheumatoid patients with a knee joint effusion participated in the study. An aqueous solution (0.1 to 0.2 ml) containing paracetamol, salicylate, diclofenac and [125I]-albumin was injected into a given joint to yield target concentrations of approximately 20 micrograms...
Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%
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Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)
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Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate
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HPLC Analysis of Benzoic Acid Derivatives on Ascentis® C18
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