M8506

Methimazole

analytical standard

• Synonym(s): 1-Methyl-2-mercaptoimidazole, 1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole, MET
• Empirical Formula (Hill Notation): C₄H₆N₂S
• CAS Number: 60-56-0
• Molecular Weight: 114.17
• Beilstein: 108646
• EC Number: 200-482-4
• MDL number: MFCD00179321
• eCl@ss: 39161002
• PubChem Substance ID: 329818061
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 200
• assay: ≥99%
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 144-147 °C (lit.)
• application(s): cleaning products; cosmetics; food and beverages; forensics and toxicology; personal care; pharmaceutical (small molecule); veterinary
• format: neat
• SMILES string: CN1C=CNC1=S
• InChI: 1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
• InChI key: PMRYVIKBURPHAH-UHFFFAOYSA-N
• Gene Information: human ... TPO(7173)

Description

General description

Methimazole is an antithyroid agent, widely used in the treatment of hyperthyroidism.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Used to model hypothyroidism in experimental animals.

Methimazole may be used as an analytical reference standard for the quantification of the analyte in biological samples using different chromatography techniques.

Packaging

25, 100 g in glass bottle

Biochem/physiol Actions

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Warning
• Hazard Statements: H302 - H317 - H319 - H361fd
• Precautionary Statements: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves