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85431

Supelco

Silylating mixture I according to Sweeley

for GC derivatization, LiChropur

Synonym(s):

Chlorotrimethylsilane – hexamethyldisilazane mixture, Sylon HTP, hexamethyldisilazane/chlorotrimethylsilane/pyridine = 2:1:10 (v/v/v), HMDS + TMCS

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

description

ready to use solution in pyridine (10 vol parts)

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

storage temp.

2-8°C

SMILES string

C[Si](C)(C)Cl.C[Si](C)(C)N[Si](C)(C)C.C[Si](C)(C)N[Si](C)(C)C

InChI

1S/2C6H19NSi2.C3H9ClSi/c2*1-8(2,3)7-9(4,5)6;1-5(2,3)4/h2*7H,1-6H3;1-3H3

InChI key

UCJNZOHHMSKSRP-UHFFFAOYSA-N

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Application

Learn more in the Product Information

Components

hexamethyldisilazane : chlorotrimethylsilane : pyridine = 2:1:10 (v/v)

Other Notes

Useful silylating mixture for the silylation of hydroxy-compounds

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Sylon is a trademark of Sigma-Aldrich Co. LLC

related product

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

68.0 °F - closed cup

Flash Point(C)

20 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

85431-BULK:
85431-VAR:
85431-10ML:4548174014318
85431-1ML:
85431-10X1ML:4548173376455
85431-25ML:


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J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Sweeley, C.C., et al.
Journal of the American Chemical Society, 85, 2497-2497 (1963)

Articles

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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