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Safety Information

ABC963

Sigma-Aldrich

Anti-phospho Mitofusin2 Antibody (Ser442)

Synonym(s):

Mitofusin-2|Transmembrane GTPase MFN2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

300

clone

polyclonal

species reactivity

human

technique(s)

inhibition assay: suitable (peptide)
western blot: suitable

General description

Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.

Immunogen

KLH-conjugated linear peptide corresponding to human phospho Mitofusin2 (Ser442).

Application

Anti-phospho Mitofusin2 Antibody (Ser442) is an antibody against phospho Mitofusin2 (Ser442) for use in Western Blotting, Peptide Inhibition Assay.

Quality

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 1.0 ug/mL of this antibody detected phospho Mitofusin2 (Ser442) in 10 ug of SH-SY5Y cell lysate.

Other Notes

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

ABC963:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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