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422686

Sigma-Aldrich

Kininogen, High Molecular Weight, Single Chain, Human Plasma

Native, single chain, high molecular weight Kininogen from human plasma.

Synonym(s):

High molecular weight kininogen

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.28

Quality Level

100

Assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

General description

Native, single chain, high molecular weight Kininogen from human plasma. Non-enzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor a-XIIa. Also circulates in plasma in complex with Factor XI, that may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Native, single chain, high molecular weight Kininogen from human plasma. Nonenzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor α-XIIa. Also circulates in plasma in complex with Factor XI and may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

422686-MG:
422686-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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