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217386

Sigma-Aldrich

Carboxy-PTIO, Sodium Salt

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Synonym(s):

Carboxy-PTIO, Sodium Salt, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na

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About This Item

Empirical Formula (Hill Notation):
C14H16N2O4 · Na
Molecular Weight:
299.28
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

dark blue

solubility

HEPES Buffer: 0.4 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.
Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2-/NO3- with a rate constant of 1 x 104 M-1sec-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nitric oxide scavenging action
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

Other Notes

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

217386-10MG:
217386-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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