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526134

Sigma-Aldrich

tert-Butyldimethylsilyl glycidyl ether

98%

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About This Item

Empirical Formula (Hill Notation):
C9H20O2Si
CAS Number:
78906-15-7
Molecular Weight:
188.34
MDL number:
MFCD02683555
UNSPSC Code:
12352100
PubChem Substance ID:
24874536
NACRES:
NA.22

Assay

98%

refractive index

n20/D 1.531 (lit.)

bp

195-197 °C (lit.)

density

0.901 g/mL at 25 °C (lit.)

SMILES string

CC(C)(C)[Si](C)(C)OCC1CO1

InChI

1S/C9H20O2Si/c1-9(2,3)12(4,5)11-7-8-6-10-8/h8H,6-7H2,1-5H3

InChI key

YANSSVVGZPNSKD-UHFFFAOYSA-N

General description

tert-Butyldimethylsilyl glycidyl ether [tert-butyl-dimethyl-(oxiran-2-ylmethoxy)silane] can be synthesized from glycidol, via hydrolytic kinetic resolution (HKR) in the presence of R-(salen)Co complex and water.

Application

tert-Butyldimethylsilyl glycidyl ether may be used to synthesize (R/S)-1-benzylamino-3-(tert-butyldimethylsilyloxy)propan-2-ol and (2R/2S)-1-(tert-butyldimethylsilyloxy)-3-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl]amino}propan-2-ol.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

158.0 °F - closed cup

Flash Point(C)

70 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

526134-10G:
526134-VAR:
526134-BULK:

Certificates of Analysis (COA)

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Synthesis of Glycidol-and Sugar-Derived Bicyclic ?-and ?/d-Amino Acids for Peptidomimetic Design.
Danieli E, et al.
European Journal of Organic Chemistry, 2005(20), 4372-4381 (2005)
Practical access to highly enantioenriched C-3 building blocks via hydrolytic kinetic resolution.
Furrow ME, et al.
The Journal of Organic Chemistry, 63(20), 6776-6777 (1998)

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