TYROBP
TYRO protein tyrosine kinase binding protein
Synonyms:
DAP12, KARAP, PLOSL
Species:
Human TYROBP (7305), Mouse Tyrobp (22177), Rat Tyrobp (361537), Zebrafish tyrobp (100101461), domestic cat TYROBP (101082964), dog TYROBP (476477), cow TYROBP (282390), sheep TYROBP (443208), naked mole-rat Tyrobp (101707522), domestic guinea pig Tyrobp (100726186)
UniProtKB ID:
Gene ID:
- Human(7305) Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
- Mouse(22177) TYRO protein tyrosine kinase binding protein
- Rat(361537) Tyro protein tyrosine kinase binding protein
- Zebrafish(100101461) TYRO protein tyrosine kinase binding protein
- domestic cat(101082964) TYRO protein tyrosine kinase binding protein
- dog(476477) TYRO protein tyrosine kinase binding protein
- cow(282390) TYRO protein tyrosine kinase binding protein
- sheep(443208) TYRO protein tyrosine kinase binding protein
- naked mole-rat(101707522) TYRO protein tyrosine kinase binding protein
- domestic guinea pig(100726186) TYRO protein tyrosine kinase binding protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DAP12 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
Anti-TYROBP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species