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Merck

TTN

titin

Synonyms:
CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD
Species:
Human TTN (7273), Mouse Ttn (22138), Rat Ttn (84015), chicken TTN (424126), dog TTN (478820), domestic cat TTN (101080315), dog TTN (478819), domestic cat TTN (751825), naked mole-rat Ttn (101717863), Domestic Rabbit TTN (100008570) ...More
UniProtKB ID:
Q8WZ42, A6NKB1, E7EQE6, E7ET18, K7ENY1, Q10465, Q10466, Q15598
Gene ID:
  • Human(7273) Summary: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
  • Mouse(22138) titin
  • Rat(84015) titin
  • chicken(424126) titin
  • dog(478820) titin
  • domestic cat(101080315) titin
  • dog(478819) titin
  • domestic cat(751825) titin
  • naked mole-rat(101717863) titin
  • Domestic Rabbit(100008570) titin
  • domestic guinea pig(100722767) titin
  • cow(540561) titin
  • sheep(101122837) titin

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Antibodies

Product Number
Description
Species Reactivity
Application
MABT75
Anti-Titin (NT/Z-domain) Antibody, clone 17D11.1, clone 17D11.1, from mouse,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
T9030
Monoclonal Anti-Titin antibody produced in mouse, clone T11, ascites fluid,
Species Reactivity
chicken, vertebrates
Application
electron microscopy
immunofluorescence
immunohistochemistry
western blot
HPA007042
Anti-TTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
WH0007273M2
Monoclonal Anti-TTN antibody produced in mouse, clone 2B3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB1400285
Monoclonal Anti-TTN antibody produced in mouse, clone 6H5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot