Skip to Content
Merck

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

Synonyms:
NACP, PARK1, PARK4, PD1
Species:
UniProtKB ID:
Gene ID:
  • Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(20617) synuclein, alpha
  • Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
  • chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
  • Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
  • dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
  • cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
  • sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)
  • naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-α-Synuclein Antibody, clone Syn211 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-phospho Histone H3.1/H3.2 Antibody (Ser87), from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, human, mouse
Application
dot blot
western blot
Anti-alpha-synuclein N103 fragment, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-alpha-Synuclein Antibody, oligomer-specific Syn33, from rabbit,
Species Reactivity
human
Application
ELISA
immunofluorescence

inhibition assay

western blot
Anti-a-Synuclein, clone 10D2 Antibody, clone 10D2, from mouse, purified by affinity chromatography,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

Proteins

Product Number
Description
Species
α-synuclein 61-140, human, ,
Species
human
Synuclein α, control peptide for AB5334P, ,
Species
human
α-Synuclein E46K human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Species
human
α-Synuclein A53T human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Species
human
α-Synuclein human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human SNCA (1),
Species
human
MISSION® esiRNA, targeting human SNCA (2),
Species
human