Skip to Content
Merck

DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Synonyms:
DOC-2, DOC2
Species:
Human DAB2 (1601), Mouse Dab2 (13132), Rat Dab2 (79128), Zebrafish dab2 (404040), domestic cat DAB2 (101096539), cow DAB2 (509221), Horse DAB2 (100066655), dog DAB2 (479353), chicken DAB2 (427449), sheep DAB2 (101104604) ...More
UniProtKB ID:
P98082, A6NES5, Q13598, Q9BTY0, Q9UK04
Gene ID:
  • Human(1601) Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(13132) disabled 2, mitogen-responsive phosphoprotein
  • Rat(79128) disabled 2, mitogen-responsive phosphoprotein
  • Zebrafish(404040) disabled homolog 2 (Drosophila)
  • domestic cat(101096539) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • cow(509221) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • Horse(100066655) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • dog(479353) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • chicken(427449) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • sheep(101104604) disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
  • naked mole-rat(101725399) Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
  • domestic guinea pig(100734816) Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1400067
Anti-DAB2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
SAB1402745
Monoclonal Anti-DAB2, (C-terminal) antibody produced in mouse, clone 1C8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB1408930
Monoclonal Anti-DAB2 antibody produced in mouse, clone 3D6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB2501881
Anti-DAB2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, human, rat
Application
ELISA
western blot
HPA028888
Anti-DAB2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
EMU177431
MISSION® esiRNA, targeting mouse Dab2,
Species
mouse
EMNC002091
MISSION® esiRNA, targeting mouse Ak017619,
Species
mouse
EMU055861
MISSION® esiRNA, targeting mouse Dab2,
Species
mouse
EHU082441
MISSION® esiRNA, targeting human DAB2,
Species
human