- Ruthenium-catalyzed mild C-H oxyfunctionalization of cyclic steroidal ethers.
Ruthenium-catalyzed mild C-H oxyfunctionalization of cyclic steroidal ethers.
The Journal of organic chemistry (2007-06-26)
Jong Seok Lee, Hui Cao, Philip L Fuchs
PMID17590044
ABSTRACT
Ruthenium-catalyzed site-specific C-H oxyfunctionalization of steroidal ethers with periodate or bromate as terminal oxidants in phosphate buffer provided the acid-sensitive C-16 hydroxy compounds in high yields. Phosphate buffer (pH 7.5) significantly inhibits formation of unwanted side products generated under more acidic reaction conditions. A key example is demonstrated at the 100 g scale.
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