An efficient catalyst system for the asymmetric transfer hydrogenation of ketones: remarkably broad substrate scope.

An efficient catalyst system for the asymmetric transfer hydrogenation of ketones: remarkably broad substrate scope.

Journal of the American Chemical Society (2006-01-26)

Manfred T Reetz, Xiaoguang Li

ABSTRACT

A BINOL-derived diphosphonite having a xanthene backbone is an excellent bidentate ligand in Ru-catalyzed 2-propanol-based transfer hydrogenation of aryl/alkyl and alkyl/alkyl ketones (ee = 76-99%). Even notoriously difficult ketones such as isopropyl methyl ketone are reduced with extraordinarily high enantioselectivity (ee = 99%).

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

682977

Sigma-Aldrich

(11bR, 11′bR)-4,4′-9,9-Dimethyl-9H-xanthene-4,5-diyl)bis-dinaphtho[2,1-d:1′, 2′-f][1,3,2]dioxaphosphepin