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Merck

Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.

Organic letters (2001-07-21)
B M Kim, S J Bae, S M So, H T Yoo, S K Chang, J H Lee, J Kang
ABSTRACT

[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.

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Descrizione del prodotto

Sigma-Aldrich
D-(−)-Tartaric acid, ReagentPlus®, 99%