- Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.
Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.
Bioorganic & medicinal chemistry (2013-07-23)
Marc P Baggelaar, Yange Huang, Ben L Feringa, Frank J Dekker, Adriaan J Minnaard
PMID23867388
ABSTRACT
A catalytic asymmetric synthesis of (S)-(-)-zearalenone is reported using asymmetric allylic alkylation for the introduction of the stereocenter. (S)-(-)-Zearalenone turned out to be a novel lipoxygenase inhibitor.