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Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.

Bioorganic & medicinal chemistry letters (2009-05-19)
Shinnosuke Hosoda, Hiroshi Aoyama, Yukinori Goto, Mohammed T A Salim, Mika Okamoto, Mariko Hashimoto, Masanori Baba, Yuichi Hashimoto
ABSTRACT

Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC(50): based on reduction of viable cell number) values of 6.2-8.4 microM and >100 microM, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV.

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Sigma-Aldrich
Diphenylmethane, 99%