- Visualizing antibody-catalyzed retro-aldol-retro-Michael reactions.
Visualizing antibody-catalyzed retro-aldol-retro-Michael reactions.
Bioorganic & medicinal chemistry letters (2001-10-26)
F Tanaka, L Kerwin, D Kubitz, R A Lerner, C F Barbas
PMID11677141
ABSTRACT
We developed a visible detection system for antibody-catalyzed retro-aldol-retro-Michael reactions. Aldolase antibody 38C2 catalyzed the reaction of substrate 1 to provide 6-bromo-2-napthol that forms a visible colored azo dye with diazonium salts. This system has potential for the screening of novel catalysts.
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