- Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C.
Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C.
Nucleosides & nucleotides (2000-01-05)
M J Comin, C A Pujol, E B Damonte, J B Rodriguez
PMID10616727
ABSTRACT
Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.
MATERIALI