- Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection.
Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection.
The Pediatric infectious disease journal (2019-04-30)
Jane R Millar, Zodumo Mvo, Nomonde Bengu, Rowena Fillis, Ken Sprenger, Philippa C Matthews, Moherndran Archary, Thumbi Ndung'u, Emily Adland, Maria C Puertas, Javier Martinez-Picado, Philip Goulder
PMID31033913
ABSTRACT
We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection.
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