- In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.
In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.
Antimicrobial agents and chemotherapy (2008-07-16)
Martin Spicher, Carole Roethlisberger, Catharina Lany, Britta Stadelmann, Jennifer Keiser, Luis M Ortega-Mora, Bruno Gottstein, Andrew Hemphill
PMID18625777
ABSTRACT
In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone.
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