- Macrocarquinoids A-C, new meroterpenoids from Sargassum macrocarpum.
Macrocarquinoids A-C, new meroterpenoids from Sargassum macrocarpum.
Journal of natural medicines (2020-09-26)
Hiromi Niwa, Shin-Ichiro Kurimoto, Takaaki Kubota, Mitsuhiro Sekiguchi
PMID32974814
ABSTRACT
The production and accumulation of advanced glycation end products (AGEs) have been implicated in diabetes and diabetic complication. This study was conducted as a search for an AGE inhibitor from brown alga, Sargassum macrocarpum. Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC50: 1.0 mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control).
MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto
Sigma-Aldrich
Glycolaldehyde dimer, crystalline, mixture of stereoisomers. Melts between 80 and 90 °C depending on stereoisomeric composition