- Spy vs. spy: selecting the best reporter for 19F NMR competition experiments.
Spy vs. spy: selecting the best reporter for 19F NMR competition experiments.
Chemical communications (Cambridge, England) (2019-01-16)
Guilherme Vieira de Castro, Alessio Ciulli
PMID30644956
ABSTRACT
Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.