1568040

Proguanil hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• Formula empirica (notazione di Hill): C₁₁H₁₆ClN₅·HCl
• Numero CAS: 637-32-1
• Peso molecolare: 290.19
• Numero MDL: MFCD01732193
• Codice UNSPSC: 41116107
• ID PubChem: 329750967
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: proguanil
• Produttore/marchio commerciale: USP
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Stringa SMILE: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H; SARMGXPVOFNNNG-UHFFFAOYSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Azioni biochim/fisiol

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P301 + P330 + P331 + P310
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable