53210-U
supelMIP® SPE - Chloramphenicol
bed wt. 25 mg, volume 10 mL , LRC, pk of 50
About This Item
Prodotti consigliati
Materiali
polypropylene tube
Livello qualitativo
Nome Commerciale
SupelMIP®
Composizione
bed wt., 25 mg
Confezionamento
pk of 50
tecniche
solid phase extraction (SPE): suitable
Volume
10 mL , LRC
applicazioni
food and beverages
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Categorie correlate
Descrizione generale
The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.
By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.
Visit www.sigma-aldrich.com/supelmip to learn more.
Applicazioni
Chloramphenicol is a broad-spectrum antibiotic that is currently banned by a number of countries including the EU, the US, and Canada. This MIP phase and associated method offer a simple, efficient, and highly selective extraction method for quantiting chloramphenicol in food products and biological matrices. Detection limits well below the minim required performance limit (MPRL) are achieved consistently.
Caratteristiche e vantaggi
- Highly selective SPE for trace analysis in complex matrices
- Achieve lower detection limits
- Significant time and cost savings
- Improved MS-compatibility
Note legali
Applicazioni
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
200.3 °F
Punto d’infiammabilità (°C)
93.5 °C
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Articoli
The method for determination of low concentrations of chloramphenicol in bovine and porcine urine was developed. Sample cleanup was performed by Molecular Imprinted Polymer (MIP) columns. Confirmatory analyses were conducted using GC/MS-NCI after derivatisation (silylation). The described method was fully validated according to CD 2002/657/EC, CCa was 0.06 ng/mL, CCb was 0.1 ng/mL. This method is considerably robust and allows to process even very dirty samples. The described procedure is very simple, low-time-consuming, provides high throughput of examinated samples, and could be used for routine screening and confirmatory analyses as well.
Contenuto correlato
SupelMIP SPE is based on molecularly imprinted polymer (MIP) technology. Each SupelMIP phase offers tailor-made selectivity for the extraction of trace analytes in complex matrixes.
Chromatograms
application for SPE, application for LC-MSIl team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
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