WH0006741M1

Monoclonal Anti-SSB antibody produced in mouse

clone 1D6-H5, purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: Anti-Sjogren syndrome antigen B (autoantigen La)
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 1D6-H5, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotipo: IgG1κ
• N° accesso Genebanck: BC001289
• N° accesso UniProt: P05455
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SSB(6741)

Descrizione

Descrizione generale

The Sjogren syndrome antigen B (SSB) gene with 11 exons contains two alternative promoters 1 (P1) and 1′ (P1′) coding for SSB protein. The gene is mapped to human chromosome 2q31.1. The gene coded for a RNA-binding protein that is ubiquitously expressed.

Immunogeno

SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Azioni biochim/fisiol

Sjogren syndrome antigen B (SSB) plays a vital role in various stages of the RNA metabolism such as RNA polymerase III protection from exonuclease digestion, processing of specific cellular and viral RNA precursors, serving as an RNA chaperone, affecting telomere homeostasis and stimulating microRNA expression. It promotes proliferation, migration and invasion of cancer cells in vitro . In addition, it also enhances tumor growth in vivo. Overexpression of the gene has been observed in various types of cancers.

Stato fisico

Solution in phosphate buffered saline, pH 7.4

Note legali

GenBank is a registered trademark of United States Department of Health and Human Services

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)