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Documenti fondamentali

SAB4503527

Sigma-Aldrich

Anti-PAR4 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Coagulation factor II receptor-like 3, F2RL3, PAR-4, Proteinase-activated receptor 4, Thrombin receptor-like 3

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About This Item

Numero MDL:
MFCD02265744
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 41 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

Q96RI0

N° accesso UniProt

Q96RI0

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... F2RL3(9002)

Descrizione generale

Anti-PAR4 Antibody detects endogenous levels of total PAR4 protein.
F2R-like thrombin or trypsin receptor 3/coagulation factor 2 receptor-like 3 (F2RL3) gene codes for protease-activated receptor 4 (PAR4) protein. PAR4 belongs to the G protein-coupled receptors (GPCRs) family. It is expressed at high levels in the lungs, pancreas, thyroid, testis, and small intestine. PAR4 gene is located on human chromosome 19p12. Anti-PAR4 antibody detects endogenous levels of total PAR4 protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human PAR4.

Immunogen Range: 29-78

Applicazioni

Anti-PAR4 antibody produced in rabbit has been used in immunoblotting (1:1000).

Azioni biochim/fisiol

Protease-activated receptor 4 (PAR4) protein is involved in vascular inflammation. It is necessary for a stable thrombus as it mediates persistent thrombin signaling in platelets. PAR4 aids pro-inflammatory actions by interacting with the bradykinin B2 receptor. It is linked to renal function and the development of chronic kidney disease (CKD).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
61939

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Gamariel Rwibasira Rudinga et al.
International journal of molecular sciences, 19(2) (2018-02-15)
Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily
W F Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(12), 6642-6646 (1998-06-17)
Protease-activated receptors 1-3 (PAR1, PAR2, and PAR3) are members of a unique G protein-coupled receptor family. They are characterized by a tethered peptide ligand at the extracellular amino terminus that is generated by minor proteolysis. A partial cDNA sequence of
Shailaja Mahajan-Thakur et al.
Journal of leukocyte biology, 96(4), 611-618 (2014-07-06)
Thrombin is not only a central factor in blood coagulation but also stimulates inflammatory processes, including monocyte responses, via activation of PARs. The signaling lipid S1P is a major determinant of monocyte function. Here, we established an interaction between S1P

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