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Key Documents

SAB4502987

Sigma-Aldrich

Anti-TSG6 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

α-induced protein 6, TSG6, tumor necrosis factor

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 31 kDa

Reattività contro le specie

human, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
western blot: 1:500-1:1000

N° accesso NCBI

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TSG6(7130)

Descrizione generale

Anti-TSG6 Antibody detects endogenous levels of total TSG6 protein.
Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) is an inflammation-associated secreted protein. It has a molecular weight of about 35 kDa. TSG-6 possesses Link and CUB_C domains, along with a with a short amino-terminal sequence. The gene encoding this protein is localized on human chromosome 2q23.3.

Immunogeno

The antiserum was produced against synthesized peptide derived from human TSG6.

Immunogen Range: 21-70

Azioni biochim/fisiol

Tumor necrosis factor (TNF)-α–stimulated gene 6 protein (TSG-6) has been implicated in regulation of cell-cell and cell-matrix interactions during inflammation and tumorigenesis. TSG-6 possesses anti-inflammatory properties. It is also known to reduce inflammatory reactions triggered by ischemia in the heart. Thus, it might have a potential role in treating heart disease with other cells such as skeletal myoblasts, fetal myoblasts and embryonic stem cells.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions.
Dyer DP, et al.
The Journal of Biological Chemistry (2016)
A Novel Allelic Variant of the Human TSG-6 Gene Encoding an Amino Acid Difference in the CUB Module CHROMOSOMAL LOCALIZATION, FREQUENCY ANALYSIS, MODELING, AND EXPRESSION.
Nentwich HA, et al.
The Journal of Biological Chemistry, 277(18), 15354-15362 (2002)
A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.
Lee T H, et al.
The Journal of Cell Biology, 116(2), 545-557 (1992)
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6.
Ryang H L, et al.
Cell Stem Cell, 5(1), 54-63 (2009)
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages
Choi H, et al.
Blood (2011)

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