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SAB4501531

Sigma-Aldrich

Anti-Prostate-specific Antigen antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

γ-seminoprotein, P-30 antigen, kallikrein- 3, kallikrein-related peptidase 3, prostate-specific antigen

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About This Item

Numero MDL:
MFCD00164722
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 28 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P07288

N° accesso UniProt

P07288

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... KLK3(354)

Descrizione generale

Anti-Prostate-specific Antigen Antibody detects endogenous levels of total Prostate-specific Antigen protein.
The prostate-specific antigen (PSA) is coded by KLK3 (kallikrein 3) gene. It is located on human chromosome 19q13.33.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Prostate-specific Antigen.

Immunogen Range: 81-130

Azioni biochim/fisiol

The prostate-specific antigen (PSA) plays a major role in sperm motility. It participates in tumor invasion and metastasis. It also plays a major role in the etiology of prostate cancer (PCa).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Single-nucleotide polymorphism rs1058205 of KLK3 is associated with the risk of prostate cancer: A case-control study of Han Chinese men in Northeast China.
Chen C and Xin Z
Medicine, 96(10) (2017)
Keke Zhang et al.
Molecular medicine reports, 17(6), 8203-8211 (2018-04-17)
The androgen receptor (AR) has a crucial role in prostate cancer. RNA‑binding protein‑mediated post‑transcriptional regulation is important in the initiation and development of cancer. The present study attempted to elucidate the mutual association of AR and RNA‑binding protein quaking (QKI)
Eric G Bluemn et al.
Cancer cell, 32(4), 474-489 (2017-10-11)
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often
Pavlo L Kovalenko et al.
The Journal of surgical research, 190(1), 177-184 (2014-04-29)
Schlafen proteins have previously been linked to leukocyte and intestinal epithelial differentiation. We hypothesized that Schlafen 12 (SLFN12) overexpression in human prostate epithelial cells would modulate expression of prostate-specific antigen (PSA) and dipeptidyl peptidase 4 (DPP4), markers of prostatic epithelial
Seung-Yon Lee et al.
Cancer letters, 354(2), 390-397 (2014-09-10)
Metformin, a diabetes drug, has been reported to inhibit the growth of prostate cancer cells. In this study, we investigated the effect and action mechanism of metformin on the function of androgen receptor (AR), a key molecule in the proliferation

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