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Documenti

S7947

Sigma-Aldrich

Stattic

≥98% (HPLC), powder

Sinonimo/i:

6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

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About This Item

Formula empirica (notazione di Hill):
C8H5NO4S
Numero CAS:
19983-44-9
Peso molecolare:
211.19
Numero MDL:
MFCD00173799
Codice UNSPSC:
12352200
ID PubChem:
329824592
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: >20 mg/mL

Stringa SMILE

[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
ZRRGOUHITGRLBA-UHFFFAOYSA-N

Applicazioni

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5

Azioni biochim/fisiol

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic is an irreversible STAT3 activation inhibitor.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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STAT5 Inhibitor III, Pimozide The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

573110

STAT5 Inhibitor III, Pimozide

STA-21 ≥95% (HPLC)

Sigma-Aldrich

SML2161

STA-21

AS1517499 ≥98% (HPLC)

Sigma-Aldrich

SML1906

AS1517499

Risedronate sodium ≥97% (HPLC)

Sigma-Aldrich

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STAT3 Inhibitor Peptide, Cell-Permeable The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.

Sigma-Aldrich

573096

STAT3 Inhibitor Peptide, Cell-Permeable

Matthew A Bill et al.
Molecular cancer, 9, 165-165 (2010-06-26)
We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. FLLL32
Doyeon Park et al.
Journal of breast cancer, 24(2), 138-152 (2021-04-06)
Melanoma-associated antigen C2 (MAGEC2) is an oncogene associated with various types of cancers. However, the biological function of MAGEC2 in circulating tumor cells remains unclear. In this study, we investigated the role of MAGEC2 using adapted suspension cells (ASCs), which
Long noncoding RNA PVT1 promotes hepatoblastoma cell proliferation through activating STAT3
Luo Z and Cao P
Cancer Management and Research, 11, 8517-8517 (2019)
Human dental pulp stem cells grown in neurogenic media differentiate into endothelial cells and promote neovasculogenesis in the mouse brain.
Luzuriaga J, et al.
Frontiers in Physiology, 10, 347-347 (2019)
Kerstin Boengler et al.
Current pharmaceutical design, 19(39), 6890-6895 (2013-04-18)
The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration
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