M2295
Myelin Basic Protein from guinea pig brain
≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain
Sinonimo/i:
MBP
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About This Item
Prodotti consigliati
Origine biologica
guinea pig brain
Saggio
≥80% (SDS-PAGE)
Forma fisica
lyophilized powder
tecniche
cell based assay: suitable
N° accesso UniProt
applicazioni
cell analysis
Temperatura di conservazione
−20°C
Informazioni sul gene
guinea pig ... MBP(100731253)
Descrizione generale
Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.
Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system). It is an auto-immunogen.
Applicazioni
Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay
Azioni biochim/fisiol
Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.
Qualità
May contain traces of urea-glycine buffer salts.
Principio
Used as a kinase substrate.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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Karine Thibault et al.
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Multiple sclerosis is a chronic inflammatory demyelinating disease, associated, in 50-80% of patients, with persistent pain. While the type of pain that affects these patients is being more documented, the mechanisms underlying this pathology are still poorly understood and animal
Sequence of guinea pig myelin basic protein.
Deibler GE
Journal of Neurochemistry, 43(1), 100-105 (1984)
Metallic gold slows disease progression, reduces cell death and induces astrogliosis while simultaneously increasing stem cell responses in an EAE rat model of multiple sclerosis
Pedersen DS, et al.
Histochemistry and Cell Biology, 138(5), 787-802 (2012)
Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats
Della VB, et al.
Frontiers in Pharmacology, 7, 787-802 (2016)
Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
Campagnoni AT, et al.
Test, 268(7), 4930-4938 (1993)
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