G113

GR 64349

>96%

• Formula empirica (notazione di Hill): C₄₂H₆₈N₁₀O₁₁S
• Numero CAS: 137593-52-3
• Peso molecolare: 921.11
• Codice UNSPSC: 12352202
• ID PubChem: 329799740
• NACRES: NA.32

Proprietà

• Livello qualitativo: 200
• Saggio: >96%
• Temperatura di conservazione: −20°C
• Stringa SMILE: CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O
• InChI: 1S/C42H68N10O11S/c1-23(2)19-32(40(61)46-27(35(45)56)15-18-64-5)52-17-14-28(42(52)63)47-41(62)34(24(3)4)51-38(59)29(20-25-11-7-6-8-12-25)49-39(60)31(22-53)50-37(58)30(21-33(54)55)48-36(57)26(44)13-9-10-16-43/h6-8,11-12,23-24,26-32,34,53H,9-10,13-22,43-44H2,1-5H3,(H2,45,56)(H,46,61)(H,47,62)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H,54,55)/t26-,27-,28-,29-,30-,31-,32-,34-/m0/s1; HVUNRXRFMQDMBO-NOJSRKIXSA-N
• Informazioni sul gene: human ... TACR2(6865) ; mouse ... TACR2(21337) ; rat ... TACR2(25007)

Descrizione

Amino Acid Sequence

Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2

Descrizione generale

Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK₂ is GR 64349 peptide.

Azioni biochim/fisiol

GR 64349 peptide acts as an agonist of neurokinin (NK₂) receptor, which leads to reduced NK₂ response to kainate and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), but not to NMDA (N-methyl-D-aspartate).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)