C1354

Monoclonal Anti-Caspase 11 antibody produced in rat

clone 17D9, purified from hybridoma cell culture

• Numero MDL: MFCD02095975
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rat
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 17D9, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: mouse
• Confezionamento: antibody small pack of 25 μL
• Concentrazione: ~1 mg/mL
• tecniche: immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.; immunohistochemistry (frozen sections): suitable; immunoprecipitation (IP): suitable
• Isotipo: IgG2a
• N° accesso UniProt: P70343
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Casp4(12363)

Descrizione

Descrizione generale

Caspases are proteases having similar structure, substrate specificity and can be divided into three subfamilies based upon their amino acid sequence homology.Monoclonal Anti-Caspase 11 (rat IgG2a isotype) is derived from the 17D9 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant p30 subunit of mouse caspase 11. Caspase 11 (also known as Ich-3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cystein proteases. Caspase 11 is an “upstream” caspase with a long prodomain. Caspase 11 is identified in murine and shares homology with the human caspase 4 and 5.

Immunogeno

recombinant p30 subunit of mouse caspase 11.

Applicazioni

Monoclonal Anti-Caspase 11 antibody can be used in immunohistochemistry and immunoprecipitation. It is also useful in immunoblotting

Azioni biochim/fisiol

Caspases are normally produced in the cell as inactive procaspases. Caspase 11 can induce apoptosis in cultured cells due to overexpression. Monoclonal antibodies reacting specifically with caspase 11 are useful tool for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable