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Merck
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Key Documents

C1108

Sigma-Aldrich

Anti-Cannabinoid Receptor 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Sinonimo/i:

Anti-CANN6, Anti-CB-R, Anti-CB1, Anti-CB1A, Anti-CB1K5, Anti-CB1R, Anti-CNR

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About This Item

Numero MDL:
MFCD01633082
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous glycerol solution

PM

antigen ~52 kDa

Reattività contro le specie

rat, human

Concentrazione

1 mg/mL

tecniche

immunocytochemistry: suitable
western blot: suitable

N° accesso UniProt

P21554

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... CNR1(1268)
rat ... Cnr1(25248)

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Immunogeno

fusion protein containing amino acids 1-99 of the human CB1 receptor.

Applicazioni

Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:250 and for immunocytochemistry at a working dilution of 1:1000.

Azioni biochim/fisiol

Cannabinoids exert their well-known physiological effects through two G-protein coupled receptors, CB1 and CB2. The cannabinoid receptor type 1 (CB1) is widely distributed in mammalian tissues, with the highest concentrations found in brain neurons while CB2 receptor function primarily in the peripheral immune system, found in spleen and may be present in the central nervous system, including the retina. The cannabinoid receptor type 1 are involved in modulation of adenylate cyclase and ion channels. It is also involved in the modulation of nociception, movement, learning and memory, emotion and many other neuronal processes. It also plays an essential role in drug addiction. CB1 receptor blockade may be useful for treatment of angiotensin II-dependent hypertension and associated metabolic syndrome.

Stato fisico

Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin, 50% glycerol, and 0.05% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Natasha L Grimsey et al.
Journal of neuroscience methods, 171(1), 78-86 (2008-04-15)
The study of endogenous cannabinoid CB1 receptor proteins in neuronal tissues and cells relies on the availability of highly specific antibodies. We have tested the ability of a series of CB1 antibodies to detect endogenous receptors in brain as well
Laura Orio et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(15), 4846-4857 (2009-04-17)
Extended access to cocaine produces an increase in cocaine self-administration in rats that mimics aspects of compulsive drug intake in human addicts. Although emerging evidence implicates the endogenous cannabinoid system in aspects of opioid and ethanol addiction, a role of
R G Pertwee
Current medicinal chemistry, 6(8), 635-664 (1999-09-02)
Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB2 receptors occur in certain non-neuronal tissues
Hajar Miranzadeh Mahabadi et al.
Molecular brain, 14(1), 89-89 (2021-06-09)
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons throughout the central nervous
C C Felder et al.
Annual review of pharmacology and toxicology, 38, 179-200 (1998-05-23)
Marijuana has been in use for over 4000 years as a therapeutic and as a recreational drug. Within the past decade, two cannabinoid receptor types have been identified, their signal transduction characterized, and an endogenous lipid agonist isolated from mammalian
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