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Merck
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Documenti

A6060

Sigma-Aldrich

Calpain Inhibitor II

powder

Sinonimo/i:

N-Acetyl-L-leucyl-L-leucyl-L-methioninal

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About This Item

Formula empirica (notazione di Hill):
C19H35N3O4S
Numero CAS:
110115-07-6
Peso molecolare:
401.56
Beilstein:
7693643
Numero MDL:
MFCD00065506
Codice UNSPSC:
12352200
ID PubChem:
24891051
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

powder

Colore

white

Solubilità

ethanol: 20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
RJWLAIMXRBDUMH-ULQDDVLXSA-N

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Applicazioni

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Azioni biochim/fisiol

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Altre note

Formerly CAS# 136632-32-1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Keduo Qian et al.
Bioorganic & medicinal chemistry letters, 21(19), 5944-5947 (2011-08-23)
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibition of the chymotrypsin-like activity of 20S proteasome. From the SAR study, we concluded that the C-3 and C-30 positions are the pharmacophores for increasing
The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4
Al Sorkhy M, et al.
The Journal of Biological Chemistry, 284(5), 2617-2627 (2009)
Zhao Dang et al.
Bioorganic & medicinal chemistry letters, 21(7), 1926-1928 (2011-03-11)
A new class of proteasome inhibitors was synthesized using lithocholic acid as a scaffold. Modification at the C-3 position of lithocholic acid with a series of acid acyl groups yielded compounds with a range of potency on proteasome inhibition. Among
Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
Ziyatdinova S, et al.
Epilepsy Research (2011)
Aneurysm: New Insights for the Healthcare Professional, 56-57 (2013)
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