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A1486

Sigma-Aldrich

Anti-ATP6AP1 (451-465) antibody produced in rabbit

IgG fraction of antiserum, PBS solution

Sinonimo/i:

Anti-16A, Anti-ATP6IP1, Anti-ATP6S1, Anti-Ac45, Anti-CF2, Anti-VATPS1, Anti-Vacuolar ATP synthase subunit S1 precursor, Anti-XAP3

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

PBS solution

PM

antigen ~52 kDa

Reattività contro le specie

human

tecniche

western blot: 1:500-1:2,000

N° accesso UniProt

Q15904

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ATP6AP1(537)

Descrizione generale

ATPase H+ transporting accessory protein 1 (ATP6AP1) is an accessory subunit of the V-ATPase. This gene is located on human chromosome Xq28. ATP6AP1 is also referred as Ac45. It is abundantly expressed a high levels in neuronal and (neuro-) endocrine cells and osteoclasts.

Immunogeno

synthetic peptide corresponding to amino acids 451-465 of human ATP6AP1

Applicazioni

Rabbit anti-ATP6AP1 (451-465) antibody can be used for western blot (1:500-1:2,000) assays.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Azioni biochim/fisiol

ATPase H+ transporting accessory protein 1 (ATP6AP1) is known to cause an X-linked N-glycosylation syndrome with liver disease. It is essential for endosomal acidification. It also participates in membrane trafficking and Ca2+-dependent membrane fusion.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

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Certificati d'analisi (COA)

Lot/Batch Number
069K2827

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Expanding the phenotype of metabolic cutis laxa with an additional disorder of N-linked protein glycosylation
Witters P, et al.
European Journal of Human Genetics, 26(5), 618-618 (2018)
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
Pareja F, et al.
Nature Communications, 9(1), 3533-3533 (2018)
Richard J Nuckels et al.
Investigative ophthalmology & visual science, 50(2), 893-905 (2008-10-07)
The vacuolar (v)-ATPase complex is a key regulator of the acidification of endosomes, lysosomes, and the luminal compartments of several cell types, tissues, and organs; however, little is know about the in vivo function of the v-ATPase complex or its
Jason J Gokey et al.
Developmental biology, 407(1), 115-130 (2015-08-09)
Asymmetric fluid flows generated by motile cilia in a transient 'organ of asymmetry' are involved in establishing the left-right (LR) body axis during embryonic development. The vacuolar-type H(+)-ATPase (V-ATPase) proton pump has been identified as an early factor in the
Fresia Pareja et al.
Nature communications, 9(1), 3533-3533 (2018-09-01)
Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations, and are characterized by abundant intracytoplasmic granules. The genetic drivers of GCTs are currently unknown. Here, we apply whole-exome sequencing and targeted sequencing analysis to reveal
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