433R-1

IMP3 (EP286) Rabbit Monoclonal Primary Antibody

• Codice UNSPSC: 12352200

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP286, monoclonal
• Descrizione: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (433R-14); vial of 0.5 mL concentrate (433R-15); bottle of 1.0 mL predilute (433R-17); vial of 1.0 mL concentrate (433R-16); bottle of 7.0 mL predilute (433R-18)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotipo: IgG
• Controllo: pancreatic ductal adenocarcinoma, placenta
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: cytoplasmic, membranous
• Informazioni sul gene: human ... IMP3(55272)

Descrizione

Descrizione generale

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 expression is at its highest during embryogenesis and silenced in normal human tissues (fibroblasts, lymphocytes, and testes are exceptions).¹ IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys.² IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues.¹ In a study of IMP3 being used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis, IMP3 was found to have high sensitivity and specificity for pancreatic ductal adenocarcinoma and detected pancreatic ductal adenocarcinoma metastases.² IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.^1,2

Qualità

IVD

IVD

IVD

RUO

Linkage

IMP3 Positive Control Slides, Product No. 433S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

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Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany