375M-9

HGAL (MRQ-49) Mouse Monoclonal Antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: MRQ-49, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (375M-94); vial of 0.5 mL concentrate (375M-95); bottle of 1.0 mL predilute (375M-97); vial of 1.0 mL concentrate (375M-96); bottle of 7.0 mL predilute (375M-98)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotipo: IgG2aκ
• Controllo: lymph node, tonsil
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: cytoplasmic
• Informazioni sul gene: human ... GCSAM(257144)

Descrizione

Descrizione generale

Human germinal center–associated lymphoma (HGAL) protein is specifically expressed in the cytoplasm of germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the interfollicular and paracortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. Anti-HGAL has the highest overall sensitivity of detecting follicular lymphoma (FL) and in detecting the interfollicular and diffuse components of FL compared with antibodies against bcl2, LMO2, CD10, and bcl6. The addition of anti-HGAL to the immunohistologic panel is beneficial in the work-up of nodal and extranodal B-cell lymphomas, and the efficacy of anti-HGAL in detecting the follicular, interfollicular, and diffuse components of FL is of particular value in the setting of variant immunoarchitectural patterns.

Qualità

IVD

IVD

IVD

RUO

Linkage

HGAL Positive Control Slides, Product No. 375S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany