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Merck
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Documenti

30030

Sigma-Aldrich

Cymarin

≥96% (HPLC)

Sinonimo/i:

K-Strophanthidin-D-cymaroside, K-Strophanthin-α

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About This Item

Formula empirica (notazione di Hill):
C30H44O9
Numero CAS:
508-77-0
Peso molecolare:
548.66
Beilstein:
101370
Numero CE:
208-087-9
Numero MDL:
MFCD00003669
Codice UNSPSC:
12352211
ID PubChem:
57648403
NACRES:
NA.77

Saggio

≥96% (HPLC)

Stringa SMILE

CO[C@H]1C[C@@H](O[C@H](C)[C@H]1O)O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6

InChI

1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1
XQCGNURMLWFQJR-ZNDDOCHDSA-N

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Applicazioni

Cymarin was used to study the effect of cardiac glycosides on vascular smooth muscles and ion transport.

Azioni biochim/fisiol

Cymarin is a cardiac glycoside and is classified as cardiotonic steroid. It inhibits ion transport by decreasing the activity of (Na-K)-ATPase.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 + H331,H373

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Iu I Pivovarov et al.
Biulleten' eksperimental'noi biologii i meditsiny, 96(8), 24-28 (1983-08-01)
Experiments on rats were made to study the character of rhythmical activity of intact heart and heart with abnormal reactivity under electrical stimulation of the blue spot (BS) and formation in it of the generator of pathologically enhanced excitation (GPEE)
[Effects of digitalis on the diastolic phase of the normal heart. Angiographic evaluation in man].
R Bolognesi et al.
Cardiologia (Rome, Italy), 33(6), 589-593 (1988-06-01)
Ting Lei et al.
Journal of Asian natural products research, 13(11), 1030-1035 (2011-10-20)
Two new compounds, along with two known compounds, were isolated from the barks of Parabarium huaitingii, and their structures were determined as 5α-pregn-6-ene-3β,17α,20(S)-triol-20-O-β-d-digitoxopyranoside (1), cymaropyranurolactone 4-O-β-d-digitalopyranosyl-(1 → 4)-O-β-d-cymaropyranosyl-(1 → 4)-O-β-d-oleandropyranosyl-(1 → 4)-O-β-d-cymaropyranoside (2), 3β,17α,20(S)-trihydroxy-5α-pregn-6-ene (3), and 5α-pregn-6-ene-3β,17α,20(S)-triol-3-O-β-d-digitalopyranoside (4) by spectroscopic methods.
E V Lopatina et al.
Bulletin of experimental biology and medicine, 146(6), 744-746 (2009-06-11)
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M)
Z B Skorzova et al.
Sudebno-meditsinskaia ekspertiza, 32(2), 35-36 (1989-04-01)
Private technique of extraction isolation and purification, chromatographic detection and photometric determination of zimarin in urine is suggested. Detection limit is 0.01 mg, determination limit is 0.1 mg of glycoside in 100 ml of urine. Method makes it possible to
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