AB1580-I

Anti-Mu Opioid Receptor Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: Mu-type opioid receptor, M-OR-1, MOR-1, Mu opiate receptor, Mu opioid receptor, MOP, hMOP, Anti-Opioid Receptor μ
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: mouse, human
• Reattività contro le specie (prevista in base all’omologia): bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology)
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• N° accesso NCBI: NP_000905
• N° accesso UniProt: P35372
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... OPRM1(4988)

Descrizione

Descrizione generale

Mu Opioid Receptor (MOP), also called Mu-type opioid receptor (MOR-1), is a receptor for natural and synthetic opioids such as beta-endorphin, endomorphin, morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. MOP functions as a class A G-protein coupled receptor (GPCR), but its down-regulation pathways vary with the agonist and may or may not be independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling, as opposed to synthetic ligands, like morphine, that trigger only low desensitization and endocytosis. Hetero-oligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. MOP is expressed in the brain and is involved in neurogenesis. MOP is the main physiological target for most clinically important opioid analgesics.

Specificità

This antibody recognizes the C-terminus of Mu Opioid Receptor. This antibody will recognize isoform 1 (45 kDa), isform 10 (55 kDa), isoform 12 (34 kDa), and isoform 13 (36 kDa).

Immunogeno

KLH-conjugated linear peptide corresponding to the C-terminus of human Mu Opioid Receptor.

Applicazioni

Detect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:1,000-4,000 dilution from a representative lot detected Mu Opioid Receptor in human cerebellum, mouse hippocampus, mouse midbrain, and rat midbrain tissue.

Qualità

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Mu Opioid Receptor in 10 µg of SH-SY5Y cell lysate.

Descrizione del bersaglio

~70 kDa observed. The calculated molecular weight is 45 kDa, however Opioid Receptor mu has been shown as a ~70-90 kDa band in western blots (Ferrer-Alcon, M., et al. (2004). Molecular Brain Research. 121(1-2):114-122).

Linkage

Replaces: AB1580

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable