605197

Thrombin-Activatable Fibrinolysis Inhibitor, Human

The Thrombin-Activatable Fibrinolysis Inhibitor, Human controls the biological activity of Thrombin-Activatable Fibrinolysis. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinonimo/i: Plasma Procarboxypeptidase B, TAFI
• Codice UNSPSC: 12352202
• NACRES: NA.25

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (SDS-PAGE)
• Forma fisica: liquid
• Attività specifica: 2-9 units/mg protein
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Native thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. ctivated by the thrombin/thrombomodulin complex by proteolytic cleavage at Arg⁹². Circulates in plasma as a zymogen at a concentration of about 50 nM. Believed to play an important role in the interaction between procoagulant, anticoagulant, and fibrinolytic systems.

Native thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. Circulates in plasma as a zymogen at a concentration of 50 nM. Activated by thrombin-thrombomodulin complex by proteolytic cleavage at Arg⁹². Believed to play an important role in interaction between the procoagulant, anticoagulant, and fibrinolytic systems.

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Definizione di unità

One unit is defined as the amount of enzyme that will hydrolyze 1 µM Hip-L-Arg per min at 25°C, pH 7.65.

Stato fisico

In 150 mM NaCl, 20 mM HEPES, pH 7.4.

Nota sulla preparazione

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Boffa, M.B., et al. 1999. Biochemistry 38, 6547.
Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable