09-126

Anti-Tribbles-1 Antibody

Upstate^®, from rabbit

• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human
• Produttore/marchio commerciale: Upstate^®
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG
• N° accesso NCBI: NP_079471
• N° accesso UniProt: Q96RU8
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TRIB1(10221)

Descrizione

Descrizione generale

The Tribbles family of proteins are kinase-like proteins that contain a kinase-like domain, but lack either a catalytic domain or a protein-protein interaction domain (2). They are believed to regulate signal processing for various pathways including MAPK, Akt, and NFkB that are involved in various aspects of development, diabetes, and cancer (1,2,3). Their involvement has been reported to regulate a number of pathways that include mitosis, cell activation, and apoptosis. They are are a family made up of three family members. Tribbles-1 (TRIB1, SKIP1, G-protein-coupled receptor induced protein, and phosphoprotein regulated by mitogenic pathways) is a modulator of MAPK action. It has been shown to directly interact with the upstream kinases MEK1 and MKK4 of Erk and JNK, respectively(1). Tribble-2 (Trib2, TRB2) has been shown to interact with Akt(2). Tribbles-3 (TRIB3, TRB3. NIPK, SKIP3) has been shown to interact with Akt and the transcription factors ATF4 and NFkB p65 (RelA). It is interaction with RelA is thought to be negative regulation. Interestingly, it has been reported to regulate Akt activation via insulin(3).

Specificità

Tribbles-1

Immunogeno

KLH-conjugated sythetic linear peptide directed against a region of the N-terminal portion of Tribbles-1.

Applicazioni

This Anti-Tribbles-1 Antibody is validated for use in IH, WB for the detection of Tribbles-1.

Qualità

routinely evaluated by western blot on lysate from HeLa cells

Descrizione del bersaglio

41 kDa

Stato fisico

100 μg in 100μL of affinity purified rabbit serum in storage buffer containing PBS with 0.05% sodium azide.

Risultati analitici

Control
HeLa

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable