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379921

Sigma-Aldrich

Hydroxylamine hydrochloride

99.995% trace metals basis

Sinonimo/i:

Hydroxylammonium chloride

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About This Item

Formula condensata:
NH2OH · HCl
Numero CAS:
5470-11-1
Peso molecolare:
69.49
Beilstein:
3539763
Numero CE:
226-798-2
Numero MDL:
MFCD00051089
Codice UNSPSC:
12352301
ID PubChem:
24863700
NACRES:
NA.22

Saggio

99.995% trace metals basis

Forma fisica

powder, crystals or chunks

pH

2.5-3.5 (20 °C, 50 g/L)

Punto di fusione

155-157 °C (dec.) (lit.)

Densità

1.67 g/mL at 25 °C (lit.)

Stringa SMILE

Cl.NO

InChI

1S/ClH.H3NO/c;1-2/h1H;2H,1H2
WTDHULULXKLSOZ-UHFFFAOYSA-N

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Applicazioni

Reactant for preparation of:
  • Organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel
  • Lamellarin D analogues as inibitors of topoisomerase I and potential antitumor agents
  • Azapeptide tocolytic agents as inhibitors of prostaglandin F2α receptor for preventing preterm labor
  • Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
  • Orally bioavailable quinoline-based antidiabetic dipeptidyl peptidase IV inhibitors targeting Lys554
  • Pyrimidine nucleoside derivatives with nitric oxide donors as antiviral agents
  • Benzyladenosine compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection
  • Naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 with improved potency in rat cystometry models of urinary incontinence

Azioni biochim/fisiol

MAO inhibitor; inhibits platelet aggregation.

Avvertenze

Warning

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Organi bersaglio

spleen

Codice della classe di stoccaggio

4.1A - Other explosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Carine B Bourguet et al.
Journal of medicinal chemistry, 54(17), 6085-6097 (2011-07-22)
The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2-one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased
Salvatore Cananzi et al.
Bioorganic & medicinal chemistry, 19(16), 4971-4984 (2011-07-26)
A novel 5-oxa-6a,8-diazaindeno[2,1-b]phenanthren-7-one scaffold was designed and synthesized as an active analogue of the cytotoxic marine alkaloid Lamellarin D. The design was based on molecular modeling of the site of interaction of Lamellarin D with DNA-topoisomerase I cleavable complex, whereas
Jun Wang et al.
Journal of the American Chemical Society, 133(35), 13844-13847 (2011-08-09)
We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogues in targeting WT
Hironobu Maezaki et al.
Bioorganic & medicinal chemistry, 19(15), 4482-4498 (2011-07-12)
Dipeptidyl peptidase IV (DPP-4) inhibition is a validated therapeutic option for type 2 diabetes, exhibiting multiple antidiabetic effects with little or no risk of hypoglycemia. In our studies involving non-covalent DPP-4 inhibitors, a novel series of quinoline-based inhibitors were designed
Shi, J.; et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 22, 899-899 (2011)
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