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Merck
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Documenti

224588

Sigma-Aldrich

5-Chlorouracil

ReagentPlus®, 99%

Sinonimo/i:

5-Chloro-2,4-dihydroxypyrimidine, 5-Chloropyrimidine-2,4(1H,3H)-dione

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About This Item

Formula empirica (notazione di Hill):
C4H3ClN2O2
Numero CAS:
1820-81-1
Peso molecolare:
146.53
Beilstein:
127173
Numero CE:
217-339-7
Numero MDL:
MFCD00006019
Codice UNSPSC:
12352100
ID PubChem:
24853447
NACRES:
NA.22

Nome Commerciale

ReagentPlus®

Saggio

99%

Forma fisica

solid

Punto di fusione

>300 °C (lit.)

Solubilità

1 M NH4OH: soluble 50 mg/mL

Stringa SMILE

ClC1=CNC(=O)NC1=O

InChI

1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
ZFTBZKVVGZNMJR-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.

Applicazioni

5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.

Note legali

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H341

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 3 Oral - Muta. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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F Kossoski et al.
The Journal of chemical physics, 140(2), 024317-024317 (2014-01-21)
We report on the shape resonance spectra of uracil, 5-fluorouracil, and 5-chlorouracil, as obtained from fixed-nuclei elastic scattering calculations performed with the Schwinger multichannel method with pseudopotentials. Our results are in good agreement with the available electron transmission spectroscopy data
M K McMillian et al.
Cell biology and toxicology, 18(3), 157-173 (2002-06-27)
A simple resazurin-based cytotoxicity assay is presented for screening of cytotoxicity in hepatocytes and liver cell lines. Human hepatoma (HepG2) cells in 96-well culture plates were exposed to known toxic (cisplatin, 5-fluorouracil, ethionine, flufenamic acid, and diflunisal) and control (transplatin
Anionradicals from 5-halouracil substituted oriented DNA after X-irradiation at low temperatures.
K Voit et al.
Radiation and environmental biophysics, 25(3), 175-181 (1986-01-01)
T Sato et al.
Environmental and molecular mutagenesis, 17(4), 258-263 (1991-01-01)
The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N'-nitro-N-nitroso-guanidine (MNNG), or benzo[a]pyrene (B[a]p). The inhibitory effects of L-ascorbic acid, glutathione, vanillin, 5-fluorouracil (5-FU)
S M Morris
Mutation research, 297(1), 39-51 (1993-07-01)
The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents after the discovery that certain tumors preferentially incorporated uracil rather than thymine into the DNA. The fluorinated derivatives are widely recognized today as effective treatment modalities, especially with
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