WRN
Werner syndrome, RecQ helicase-like
Sinonimi:
RECQ3, RECQL2, RECQL3
Specie:
Human WRN (7486), Mouse Wrn (22427), Rat Wrn (290806), cow WRN (505061), sheep WRN (101106742), Domestic Rabbit WRN (100341925), naked mole-rat Wrn (101724469), domestic guinea pig Wrn (100719896), Zebrafish wrn (569495), chicken WRN (422505) ...Più
ID UniProtKB:
ID gene:
- Human(7486) Summary: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
- Mouse(22427) Werner syndrome homolog (human)
- Rat(290806) Werner syndrome
- cow(505061) Werner syndrome, RecQ helicase-like
- sheep(101106742) Werner syndrome, RecQ helicase-like
- Domestic Rabbit(100341925) Werner syndrome, RecQ helicase-like
- naked mole-rat(101724469) Werner syndrome, RecQ helicase-like
- domestic guinea pig(100719896) Werner syndrome, RecQ helicase-like
- Zebrafish(569495) Werner syndrome
- chicken(422505) Werner syndrome
- domestic cat(101095574) Werner syndrome, RecQ helicase-like
- dog(493997) Werner syndrome, RecQ helicase-like
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Monoclonal Anti-WRN, clone 195C, purified from hybridoma cell culture,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1, clone 20A11.1, from mouse,
Reattività con
human
Applicazione
western blot
Monoclonal Anti-WRN antibody produced in mouse, clone 3C11, purified immunoglobulin, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-WRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-WRN, (C-terminal) antibody produced in mouse, clone 2F7, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot
western blot