PTEN
phosphatase and tensin homolog
Sinonimi:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Specie:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), domestic cat PTEN (101091813), dog PTEN (403832), chicken PTEN (423675), cow PTEN (540786), sheep PTEN (101119351), domestic guinea pig Pten (100723659)
ID UniProtKB:
ID gene:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- naked mole-rat(101714930) phosphatase and tensin homolog
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-PTEN antibody, Rabbit monoclonal, clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody,
Reattività con
dog, frog, human, mouse
Applicazione
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse, rat
Applicazione
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN Antibody, clone A2b1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
bovine, canine, feline, human, monkey, mouse, porcine, rat
Applicazione
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-PTEN antibody, Rabbit monoclonal, clone SP170, recombinant, expressed in proprietary host, affinity isolated antibody,
Reattività con
dog, human, mouse
Applicazione
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot